Lecture 026: Extra Credit Help

Here are directions for completing the extra credit for this class. In the screencast I show how to:
1) Download ChemSketch (only for Drexel students)
2) Use wikipedia and Google scholar to find an article with a relevant synthetic step.
3) Draw out the single step reaction with ChemSketch.
4) Use Paint to convert the ChemSketch work into a bitmap file.
5) Create a Flickr account to upload the bitmap file and create a tag. (Everyone in my classes use at least the "orgo" tag in Flickr.)
6) Find the url referencing the picture in Flickr using properties and insert into a blog post. (I also go through creating a Blogger account)
7) Give a brief description of the reaction and link to at least one peer-reviewed article.

Notice that all the services are completely free. A freeware version of Chemsketch is available here. I don't know how it compares to the Drexel version.

The example I used was the last step in the synthesis of ibuprofen - the hydrolysis of a nitrile. This is what it looks like.

Remember the last day to have the extra credit work done is Friday June 3, 2005 at midnight.

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There is no pdf for this lecture.

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Lecture 025: test 2 review

I gave the solutions to the extra enol problems I posted on Monday and answered questions about the test.

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Lecture 025 pdf

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Lecture 024: prob 12 d-h

We finished problem 12 on enol chemistry and completed the list of the patterns to look for in these syntheses. At the end of class I put up a few more problems of varying difficulty then assisted students in small groups. I'll post the solution to these on Wednesday.

The test will be available Wednesday afternoon, a little earlier because Sunday and Monday Korman is closed. I will answer questions on Wednesday concerning the test then if there is any time left we'll do another Wheel of Orgo. Online students make sure to email me your questions.

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Lecture 024

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Lecture 023: problem 12 a-d

We did some enol chemistry synthesis problems. If you are having trouble with this section make sure to see me after class or schedule an appointment so I can see how you are approaching the problems.

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Lecture 023 pdf

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Lecture 022: Wheel of Orgo 4

Another round of Wheel of Orgo. This time Sri won. All of the syntheses were designed to practice enol reactions.

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Lecture 022 pdf

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Lecture 021: rest of prob 11

We finished problem 11 (j-p) on enol reactions. It was a mix of Claisen condensations, malonate ester and acetoacetate ester syntheses. The last problem was an example of a Robinson annulation.

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Lecture 021 pdf

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Lecture 020: Wheel of Orgo 3

We played another Wheel of Orgo with the target products vanillin, TNT and DEET.
Mihir won this one.

I reduced the resolution of the Flash presentation to 800x600 so you don't need to scroll if you are running you desktop at 1024x768. For all prior lectures, you can avoid scrolling by increasing the resolution of your screen.

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Lecture 020 pdf

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Lecture 019: prob 11

We covered most of problem 11 about enol reactions.
We will resume Wheel of Orgo on Friday.

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Lecture 019 pdf

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Lecture 018: Wheel of Orgo II

We played "Wheel of Orgo" again today, with the modification that I only counted a point for reactions only if they were correct. Again 3 points for completing the synthesis. We did 2 relatively simple syntheses then started one difficult one (vanillin). We didn't get the chance to finish that one so we'll resume next time. Again Sujeet ended up with the most points at the end.

I would encourage you to think of ways of finishing this synthesis with the reactions we have learned. It is a good way of consolidating the material in this class. You don't need to participate, you can pass your turn and you can join the game in progress.

If you are taking the class online and would like to participate in a future Wheel of Orgo session email me so that I can plan future sessions.

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Lecture 018 pdf

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Lecture 017: Review for Test 1 Make-up

Review from email questions, class questions and the questions most wrongly answered from test 1.

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Lecture 017 pdf

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Lecture 016: problems 8-10

Carboxylic Acids and Derivatives problems done today. Remember to email me your questions for the pre-makeup review session on Wednesday.

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Lecture 016 pdf

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